| ncRNA name | hsa-miR-18a |
| ncRNA Category | miRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | RB cell lines Y79 and WERI-RB1 |
| Methods | qPCR, flow cytometry, MTT assay, cell cytotoxicity assay |
| Expression pattern | up-regulated |
| Functional description | We focused on the pri-miRNA-17∼92 aptamer (pri-apt), which can potentially replace the mix of five antagomirs by one aptamer that function to abrogate the maturation of miR-17, miR-18a, and miR-19b (P<0.05) for targeting RB. Cellular changes upon transfecting the pri-apt led to S-phase arrest in WERI-RB1 cells and onset of apoptosis in both Y79 and WERI-RB1 cell lines. |
| PubMed ID | 25513843 |
| Year | 2015 |
| Title | Blocking the maturation of OncomiRNAs using pri-miRNA-17∼92 aptamer in retinoblastoma. |
| Drug-related ncRNA | NO |
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